It was very hard to choose a piece of hardware because I have three that I consider indispensable. But for this post, I decided on my trusty Lexmark 83 printer/scanner/copier/fax machine. I've had this for a number of years, and only had one problem (a loose carriage band) which was easily fixed with a call to tech support. I use my four-in-one daily, and of course, where would Scanfest be without it? The only feature I've never been able to figure out is the fax, and since only I do that about once a year, I just use the machine at work.
Again, I have several favorite software programs for a variety of purposes, including genealogy. Right now, I would have to choose my RootsMagic program. I absolutely love the SourceWizard that comes with it, which makes citing my sources so much easier than looking up each entry in Elizabeth Shown Mills's books!
And I have to agree with many of my fellow geneabloggers: Google is absolutely indispensable when it comes to online genealogy. I use the following features either many times a day or several times a week, mainly in relation to genealogy: Search, Images, Maps, Gmail, iGoogle, Blogger, Reader, Analytics, Calendar, Picasa, Chat, Earth, Toolbar, Web Accelerator, and Docs.